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Aesthetic specialists on Fresha, the world’s top-rated beauty and wellness booking platform, are reporting a surge in demand for polynucleotide injections – the regenerative treatment tipped to be the next big thing after fillers.
Why Clients Are Asking for It
Unlike Botox, which relaxes muscles, or fillers, which add volume, polynucleotides work at a cellular level. Derived from purified DNA fragments, they stimulate fibroblasts to regenerate collagen and elastin, which repairs skin and improves hydration, creating natural-looking results without the ‘frozen’ or ‘overfilled’ look.
Specialists on the Fresha app say clients are drawn to benefits such as:
- Skin regeneration – firmer, more youthful skin
- Improved hydration – plumper, more elastic texture
- Anti-inflammatory effect – calmer, more even skin tone
- Subtle rejuvenation – especially effective for under-eyes and neck
- Compatibility – works well alongside fillers, PRP, or microneedling
An aesthetics specialist on the Fresha Marketplace says:
“Polynucleotides are changing the game. Clients no longer want dramatic changes – they want natural improvements in skin quality. We’re seeing more requests for PN than ever before, especially as awareness grows on TikTok and in the press.”
The ‘Next Evolution’ of Injectables
While Botox has dominated for decades, Fresha practitioners say polynucleotides appeal to a new wave of patients who want treatments that regenerate rather than freeze.
“Botox and fillers will always have their place, but polynucleotides are part of a bigger movement towards regenerative aesthetics. For many clients, it feels like the future of injectables.”
Risks and Considerations
Like all injectables, side effects include redness, swelling, or bruising. A typical treatment plan involves 2–3 sessions, with results building gradually over time. PN is not suitable during pregnancy, breastfeeding, or for those with allergies to fish proteins.
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