Nothing beats the thrill of hitting the great open road and with over four million miles of roads to explore across America, there are countless road trips to rival the iconic Route 66.

From dramatic mountain ranges and lakes, to beaches and vineyards, Visit the USA rounds up five alternative U.S. road trips…

  1. American Road Trips for 2022 – Overseas Highway, Miami to Key West, Florida

Often referred to as the ‘Highway that Goes to Sea’, the Overseas Highway spans 113 miles and has 42 bridges connecting Key Largo to Key West, offering breathtaking views of the Atlantic Ocean. Experience a scenic drive through the Sunshine State, surrounded by turquoise sea and white sandy beaches, whilst stopping off for snorkelling at John Pennekamp Coral Reef State Park in Key Largo or swimming with dolphins at the halfway point of Marathon. Other highlights include ‘driving on water’ along Seven Mile Bridge and soaking up the picturesque landscapes of Islamorada. 

Bon Voyage offers a 10-day trip from Miami to Key West, from £2,295 per person, based on two people sharing. The price includes return U.K. flights, domestic flight between Miami and Key West, 10 nights accommodation and car hire on leaving Key West. To book, visit:  

  1. American Road Trips for 2022 – Natchez Trace Parkway, Alabama to Tennessee 
American Road Trips for 2022

With no billboards, no stop signs and very little traffic, the Natchez Trace Parkway was built for a road trip. Along the way, drivers can admire wildlife and waterfalls or stop for a hike as they drive along the 444 miles through Tennessee, Mississippi and Louisiana. Winding through the southern states, travellers can pay homage to the king of rock ‘n’ roll, by visiting Elvis’ birthplace in Tupelo and his mansion at Graceland, or enjoy live music in Nashville and Alabama, the best places to hear authentic American soul and country music. 

Freedom Destinations offers a 15-day motorhome ‘Rhythms of the South’ holiday, from £1,289 per person including flights and based on two people sharing, travelling in November. Includes a fully equipped motorhome and pre-paid mileage based on route. To book, visit 

  1. American Road Trips for 2022 – Pacific Highway, Sonoma County 
American Road Trips for 2022

Known for its spectacular wine and legendary vineyards, a relaxed road trip through Sonoma Valley, California is guaranteed to please. Witness the sweeping skyline of San Francisco, before journeying along Highway 1, from Bodega Bay to Gualala River, discovering more than 50 miles of dramatic Pacific coastline. Travellers can stop enroute to stroll along Doran Beach, boat-watch in the quaint harbours, or even try their luck at whale watching in Bodega Head. A visit to Sonoma Coast Vineyards is the perfect place to sample homemade Pinot Noir and Chardonnay, whilst the final stop in Jenner is the ideal spot to sip homemade coffee in small-town cafes. 

Audley Travel offers a nine-day, self-drive journey through California’s wine regions, from £5,800 per person based on two adults sharing. Price includes scheduled international flights from a choice of UK airports, car hire and eight nights in luxury hotel accommodation.  To book, visit  

  1. American Road Trips for 2022 – Great Lakes, Lake Michigan 

From Chicago, Illinois to Milwaukee, Wisconsin, The Great Lakes road trip winds along scenic roads and shorelines, surrounded by towering lighthouses and epic lake views. Whilst in Chicago, travellers can walk along the Navy Pier that stretches out over Lake Michigan, or even take a cruise across it. In Mackinac County, roadtrippers can experience ‘the jewel of the great lakes’, Mackinac Island, and marvel at the spectacular view of lush forests, limestone rock formations and sea caves, atop the Sleeping Bear Dunes.  

Discover North America offers a 14-night ‘Classic Great Lakes’ trip through Chicago to Milwaukee, from £2,199 per person, based on two adults sharing and departing 1 September 2022. Price includes 14 nights in luxury hotel accommodation and 12 days Full-Size rental including zero excess, extra drivers. To book, visit:  

  1.  American Road Trips for 2022Great River Road, Minneapolis to New Orleans 
American Road Trips for 2022

Intersecting through 10 states, this Great River Road trip along the Mississippi river is an experience like no other. Travellers can visit the famous Gateway Arch, towering 630 feet over the Mississippi River in St Louis or enjoy views of the city from a sunset hot air balloon ride in Galena, Illinois. On the final leg of the journey in New Orleans, it’s worth a stop at the Plaquemine Lock State Historic Site and venturing through the Maurepas Swamp to potentially catch a glimpse of an alligator. 

America As You Like It offers a 14-night ‘Great River Road Fly-Drive’ trip through Minneapolis to New Orleans, from £1,555 based on travel in October 2022. The price includes return flights, accommodation and car hire. To book, visit  

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